Department of Genetics Publications, 2000

Adachi, T., Wang, J., and Wang, X.L. Age-related change of plasma extracellular-superoxide dismutuase. Clin. Chim. Acta 290:169-178, 2000. [Article] [Full Text Article in PDF / Full Text Article in HTML]

Adkins, R.M., VandeBerg, J.L., and Li, W.-H. Molecular evolution of growth hormone and receptor in the guinea pig, a mammal unresponsive to growth hormone. Gene 246:357-363, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Almasy, L. and Blangero, J. Challenges for genetic analysis in the 21st century: Localizing and characterizing genes for common complex diseases and their risk factors. GeneScreen 1:113-116, 2000. [Article Abstract]

Anderson, T.J.C. and Day, K.P. Geographical structure and sequence evolution as inferred from the Plasmodium falciparum S-antigen locus. Mole. Biochem. Parasitol. 106:321-326, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Anderson, T.J.C., Haubold, B., Williams, J.T., Estrada-Franco, J.G., Richardson, L., Mollinedo, R., Bockarie, M., Mokili, J. Mharakurwa, S., French, N., Whitworth, J. Velez, I.D., Brockman, A.L., Nosten, F., Ferreeira, M.U., and Day, K.P. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Molec. Biol. Evol. 17(10):1467-1482, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Anderson, T.J.C., Paul, R.E.L., Donnelly, C.A., and Day, K.P. Do malaria parasites mate non-randomly in the mosquito midgut? Genet. Res. 75:285-296, 2000. [Article Abstract] [Full Text Article in PDF]

Anderson, T.J.C., Su, X.-Z., Roddam, A., and Day, K.P. Complex mutations in a high proportion of microsatellite loci in the protozoan parasite Plasmodium falciparum. Molec. Ecol. 9: 1599-1608, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Bazzocchi, C., Jamnongluk, W., O'Neill, S.L., Anderson, T.J.C., Genchi, C., and Bandi, C. WSP sequences from the Wolbachia of filarial nematodes. Current Microbiology 41(2):96-100, 2000. [Article Abstract]

Berg, S., Djurovic, S., Rainwater, D.L. Gene encoding the apo(a)protein is LPA (letter to the editor). Atherosclerosis 148:203, 2000. [Full Text Article in PDF]

Blangero, J., Williams, J.T., and Almasy, L. Quantitative trait locus mapping using human pedigrees. Hum. Biol. 72(1):35-62, 2000. [Article Abstract]

Blangero, J., Williams, J.T., and Almasy, L. Robust LOD scores for variance component-based linkage analysis. Genet. Epidemiol. 19 (Suppl 1):S8-S14, 2000. [Article Abstract] [Full Text Article in PDF]

Burke, J.P., Duggirala, R., Hale, D.E., Blangero, J., and Stern, M.P. Genetic basis of acanthosis nigricans in Mexican Americans and its association with type 2 diabetes-related phenotypes. Hum. Genet. 106:467-472, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Cai, H., Wang, X.L., Wilcken, D.E.L. Genetic polymorphism of heparan sulfate proteoglycan (Perlecan, HSPG2), lipid profiles and coronary artery disease in the Australian population. Atherosclerosis 148:125-129, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Chan, D.K.Y., Mellick, G., Cai, H., Wang, X.L., Ng, P.W., Pang, C.P., Woo, J., and Kay R. The alpha-synuclein gene and Parkinson's disease in a Chinese population. Archives of Neurology 57:501-503, 2000. [Article Abstract]

Chen, Y.-S., Olckers, A., Schurr, T.G., Kogelnik, A., Huoponen, K., and Wallace, D.C. Mitochondrial DNA variation in the Southern African Kung and Khwe and their genetic relationships to other African populations. Am. J. Hum. Genet. 66:1362-1383, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Cole, S.A., Mitchell, B.D., Hsueh, W.-C., Pineda, P., Beamer, B.A., Shuldiner, A.R., Comuzzie, A.G., Blangero, J., and Hixson, J.E. The Pro12Ala variant of peroxisome proliferator-activated receptor-(2 (PPAR-(2) is associated with measures of obesity in Mexican Americans. Int. J. of Obesity 24:522-524, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Comuzzie, A.G., Almasy, L., Cole, S., Boss, O., Giacobino, J.-P., Muzzin, P., Stern, M.P., MacCluer, J., Blangero, J., and Hixson, J. Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans. Int. J. Obes. Relat. Metab. Disord. 24:1065-1068, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Duggirala, R., Arya, R., Blangero, J., and Crawford M. Genetic and environmental determinants of variation in phenotypes related to coronary heart disease and renal function in the Mennonites. In M.H. Crawford (ed.) Different Seasons: Biological Aging of Mennonites of Midwestern United States, MH Crawford (ed). University of Kansas, Lawrence, KS, pp 83-99, 2000.

Duggirala, R., Blangero, J., Almasy, L., Dyer, T.D., Williams, K.L., Leach, R.J., O'Connell, P., and Stern, M.P. A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Am. J. Hum. Genet. 66:1237-1245, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Ertekin-Taner, N., Graff-Radford, N., Younkin, L.H., Eckman, C., Baker, M., Adamson, J., Ronald, J., Blangero, J., Hutton, M., and Younkin, S.G. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 290:2303-2304. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Escamilla, M.A., DeMille, M.C., Benavides, E., Roche, E., Almasy, L., Pittman, S., Hauser, J., Lew, D.F., Freimer, N.B., and Whittle, M.R. A minimalist approach to gene mapping: Locating the gene for Acheiropodia by homosygosity analysis. Am. J. Hum. Genet. 66:1995-2000, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Fu, W., Dudman, N.P.B., Perry, M.A., Yang, K., and Wang, X.L. Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine. Biochemical & Biophysical Research Communication 271:47-53, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Göring, H.H.H., and Terwilliger, J.D. Linkage analysis in the presence of errors I: complex-valued recombination fractions and complex phenotypes. Am. J. Hum. Genet. 66:1095-1106, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Göring, H.H.H., and Terwilliger, J.D. Linkage analysis in the presence of errors II: marker-locus genotyping errors modeled with hypercomplex recombination fractions. Am. J. Hum. Genet. 66:1107-1118, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Göring, H.H.H., and Terwilliger, J.D. Linkage analysis in the presence of errors III: marker loci and their map as nuisance parameters. Am. J. Hum. Genet. 66:1298-1309, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Göring, H.H.H., and Terwilliger, J.D. Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. Am. J. Hum. Genet. 66:1310-1327, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Hamill, J., Sidky, H., Spielbauer, R.H., Subedi, J., Singh, R., Blangero, J., and Williams-Blangero, S. A brief report of some Jirel vocabulary. Contributions to Nepalese Studies, January:79-88, 2000.

Hamill, J., Sidky, H., Spielbauer, R.H., Subedi, J., Singh, R., Blangero, J., and Williams-Blangero, S. Preliminary ethno-semantics of the Avifauna vocabulary in Jirel. Contrib. Nepal. Studies January:53-77, 2000.

Hamill, J., Sidky, H., Subedi, J., Spielbauer, R.H., Singh, R., Blangero, J., and Williams-Blangero, S. Some sociocultural consequences of transportation development in the Jiri Valley, Nepal. Contrib. Nepal. Studies January:89-95, 2000.

Hixson, J.E., and Blangero, J. Genomic searches for genes that influence atherosclerosis and its risk factors. Ann. NY Acad. Sci. 902:1-7, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Hsueh, W.C., Mitchell, B.D., Arburomia, R., Pollin, T., Sakul, H., Gelder Ehm, M., Michelsen, B.K., Wagner, M.J., St. Jean, P.L., Knowler, W.C., Burns, D.K., Bell, C.J., and Shuldiner, A.R. Diabetes in the old order Amish: characterization and heritability analysis of the Amish Family Diabetes Study. Diabetes Care 23(5):595-601, 2000. [Article Abstract] [Full Text Article in PDF]

Hsueh, W.-C., Mitchell, B.D., Hixson, J.E., and Rainwater, D.L. Effect of apo E polymorphism on plasma lipoproteins in Mexican Americans. Ann. of Epidemiol. 10:524-531, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Hsueh, W.-C., Mitchell, B.D., Schneider, J.L., Wagner, M., Bell, C.J., Nanthakamur, E., and Shuldiner, A.R. A QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in the Old Order Amish. Circulation 101:2810-2816, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Iturria, S.J. and Blangero, J. An EM algorithm for variance-component linkage analysis with multiple phenotypes. Ann. Hum. Genet. 64:349-362, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Kissebah, A.H., Sonnenberg, G.E., Myklebust, J., Goldstein, M., Broman, K., James, R.G., Marks, J.A., Krakower, G.R., Jacob, H.J., Weber, J., Martin, L., Blangero, J., and Comuzzie, A.G. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl. Acad. Sci. USA 97(26):14478-14483, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Kramer, J.A., McCarrey, J.R., Djakiew, D., and Krawetz, S.A. Human spermatogenesis as a model to examine gene potentiation. Mol. Reprod. Devel. 56:254-258, 2000. [Article Abstract]

Kusewitt, D.F., Hubbard, G.B., Warbritton, A.R., McLesky, S.W., Miska, K.B., Henkel, R.D., and Robinson, E.S. Cellular origins of ultraviolet radiation-induced corneal tumors in Monodelphis domestica. J. Comp. Pathol. 123:88-95, 2000. [Article Abstract]

Lynch, J., Wang, X.L., and Wilcken, D.E.L. Body mass index in Australian children: recent changes and relevance of ethnicity. Archives of Disease in Childhood 82:16-20, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Mahaney, M.C., Czerwinski, S.A., Adachi, T., Wilcken, D.E.L., and Wang, X.L. Plasma levels of extracellular superoxide dismutase in an Australian population: Genetic contribution to normal variation and correlations with plasma nitric oxide and apolipoprotein A-I levels. Arterioscler. Thromb. Vasc. Biol. 20:683-688, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Martin, L.J. and Crawford, M.H. Aging and sexual dimorphism in clinical blood chemistries of Mennonites. In: Different Seasons: Biological Aging Among the Mennonites of Midwestern United States. M.H. Crawford, (eds.) University of Kansas Press, Lawrence, KS, pp. 77-81, 2000.

Martin, L.J., Crawford, M.H., Koertvelyessy, T., Keeping, D., Collins, M., and Huntsman, R. The population structure of ten Newfoundland outports. Hum. Biol. 72:997-1014, 2000. [Article Abstract]

Mitchell, B.D., Cole, S.A., Bauer, R.L., Iturria, S.J., Rodriguez, E.A., Blangero, J., MacCluer, J.W., and Hixson, J.E. Genes influencing variation in serum osteocalcin concentrations are linked to markers on chromosomes 16q and 20q. J. Clin. Endocrinol. Metab. 85:1362-1366, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Mitchell, B.D., Cole, S.A., Hsueh W.-C., Comuzzie, A.G., Blangero, J., MacCluer, J.W. and Hixson, J.E. Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans. Diabetes 49:513-516, 2000. [Article Abstract] [Full Text Article in PDF]

Nair, S., Ha, J., and Rogers, J. Nineteen new microsatellite DNA polymorphisms in pigtailed macaques (Macaca nemestrina). Primates 41:343-350, 2000. Nguyen T.V., Blangero, J., and Eisman, J.A. Genetic epidemiological approaches to the search for osteoporosis genes. J. Bone Miner. Res. 15:392-401, 2000. [Article Abstract] [Full Text Article in HTML]

North, K.E., MacCluer, J.W., Cowan, L.D., and Howard, B.V. Gravidity and parity in post-menopausal American Indian women: The Strong Heart Study. Hum. Biol. 72(3):397-414, 2000. [Article Abstract]

North, K.E., Martin, L.J., and Crawford, M.H. The origins of the Irish Travellers and the genetic structure of Ireland. Ann. Hum. Biol. 27(5):453-465, 2000. [Article Abstract] [Full Text Article in PDF]

Rainwater, D.L. Lipoprotein correlates of LDL particle size. Atherosclerosis 148(1):151-158, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Rainwater, D.L., Mitchell, B.D., Comuzzie, A.G., VandeBerg, J.L., Stern, M.P., and MacCluer, J.W. Association among 5-year changes in weight, physical activity, and cardiovascular disease risk factors in Mexican Americans. Am. J. Epidemiol. 152:974-982, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Robinson, E.S., Hill, R., Kripke, M.L., and Setlow, R. The Monodelphis melanoma model: initial report on large ultraviolet A exposures of suckling young. Photochem. Photobiol. 71:743-746, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Robinson, E.S., Hubbard, G.B. and Dooley, T.P. Metastatic melanoma in an adult opossum (Monodelphis domestica) after short-term intermittent UVB exposure. Arch. Dermatol. Res. 292:469-471, 2000. [Article Abstract]

Rogers, J. Molecular genetic variation and population structure in Papio baboons. In Old World Monkeys, P. Whitehead and C.J. Jolly (eds.), pp. 57-76, Cambridge University Press, 2000.

Rogers, J., Mahaney, M.C., Witte, S.M., Nair, S., Newman, D.E., Wedel, S., Rodriguez, L.A., Rice, K.S., Slifer, S.H., Perelygin, A., Slifer, M., Palladino-Negro, P., Newman, T., Chambers, K., Joslyn, G., Parry, P., and Morin, P.A. A genetic linkage map of the baboon (Papio hamadryas) based on human microsatellite polymorphisms. Genomics 67:237-247, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Schurr, T.G. mtDNA variation in Native Americans and Siberians and its implications for the peopling of the New World. Am. Scientist 88:246-253, 2000. [Article Abstract]

Sidky, H., Hamill, J., Subedi, J., Spielbauer, R.H., Singh, R., Blangero, J., and Williams-Blangero, S. Social organization, economy and kinship among the Jirels of Eastern Nepal. Contrib. Nepal. Studies, January:5-22, 2000.

Sidky, H., Spielbauer, R.H., Subedi, J., Hamill, J., Singh, R., Blangero, J., and Williams-Blangero, S. Jirel religion: A preliminary look at the rites and rituals of the Jirels of Eastern Nepal. Contrib. Nepal. Studies, January:23-37, 2000.

Sidky, H., Spielbauer, R.H., Subedi, J., Hamill, J., Singh, R., Blangero, J., and Williams-Blangero, S. Phombos: A look at traditional healers among the Jirels of Eastern Nepal. Contrib. Nepal. Studies, January:39-52, 2000.

Sinsheimer, J.S., Blangero, J., and Lange, K. Gamete-competition models. Am. J. Hum. Genet. 66:1168-1172, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Soria, J.M., Almasy, L.A., Souto, J.C., Tirado, I., Borell, M., Mateo, J., Slifer, S., Stone, W., Blangero, J., and Fontcuberta, J. Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis. Blood 95:2780-2785, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Souto, J.C., Almasy, L., Borrell, M., Gari, M., Martinez, E., Mateo, J., Stone, W.H., Blangero, J., and Fontcuberta, J. Genetic determinants of hemostasis phenotypes in Spanish families. Circulation 101:1546-1551, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Souto, J.C., Almasy, L., Borrell, M., Mateo, J., Soria, J.M., Blanco-Vaca, F., Coll, I., Felices, R., Stone, W., Fontcuberta, J., and Blangero, J. Genetic susceptibility to thrombosis and its relationship with physiological risk factors: The GAIT Study. Am. J. Hum. Genet. 67:1452-1459, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Souto, J.C., Almasy, L., Muniz-Diaz, E., Soria, J.M., Borrell, M., Bayen, L., Mateo, J., Madoz, P., Stone, W., Blangero, J., and Fontcuberta, J. Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, Factor VIII, and activated partial thromboplastin time. Arterioscler. Thromb. Vasc. Biol. 20:2024-2028, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Subedi, J., Sidky, H., Hamill, J., Spielbauer, R.H., Singh, R., Blangero, J., and Williams-Blangero, S. Jirels, Jiri and politics: An overview. Contrib. Nepal. Studies, January:117-126, 2000.

Subedi, J., Subedi, S., Sidky, H., Singh, R., Blangero, J., and Williams-Blangero, S. Health and health care in Jiri. Contrib. Nepal. Studies, January:97-104, 2000.

Tausig, M., Subedi, S., Subedi, J., Ross, J., Broughton, C.L., Singh, R., Blangero, J., and Williams-Blangero, S. Mental illness in Jiri, Nepal. Contrib. Nepal. Studies, January:105-115, 2000.

Terwilliger, J.D. and Göring, H.H.H. A review of gene mapping in the 20th and 21st centuries: statistical methods, data analysis, and experimental design. Hum. Biol 72:63-132, 2000. [Article Abstract]

Verrills, N.M., Walsh, B.J., Harry, J., Hains, P.G. and Robinson, E.S. Cross-matching marsupial proteins with human databases: Proteome analysis of cells from UV-induced skin tumours of an opossum (Monodelphis domestica). Electrophoresis 21:3810-3822, 2000. [Article Abstract] [Full Text Article in PDF]

Wang, J., Marker, P.H., Belcher, J.D., Wilcken, D.E.L., Vercellotti, G.M., and Wang, X.L. Human cytomegalovirus immediate early proteins elevated p53 expression but did not sequester p53 in cytoplasm. FEBS Lett 474:213-216, 2000. [Article Abstract] [Full Text Article in PDF]

Wang, J., Trudinger, B., Duarte, N., Wilcken, D.E.L., and Wang, X.L. Elevated circulating homocyst(e)ine levels in placental vascular disease and associated preeclampsia. Br. J. Obs. Gyn. 107:935-938, 2000. [Article Abstract]

Wang, X.L. Cigarette smoking, DNA variants in endothelial nitric oxide synthase gene and vascular disease. Contrib. Nephrol. 130:53-67, 2000. [Article Abstract]

Wang, X.L. Cranney, G., and Wilcken, D.E.L. Lp(a) and conventional risk profiles predict the severity of coronary artery stenosis in high-risk hospital-based patients. Australian and New Zealand J. of Med. 30:333-338, 2000. [Article Abstract]

Wang, X.L. and Oosterhof, J. Tumour necrosis factor G-308A polymorphism and risk for coronary artery disease. Clin. Sci. 98:435-437, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]

Wang, X.L., Sim, A.S., Wang, M.X., Murrell, G.A.C., Trudinger, B., and Wang, J. Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett. 471:45-50, 2000. [Article Abstract] [Full Text Article in PDF / Full Text Article in HTML]

Wang, X.L. and Wang, J. Endothelial nitric oxide snythase gene polymorphism and vascular disease. Molec. Genet. Metab. 70:200-207, 2000. [Article Abstract]

Watson, D., Whicker, A., Loebel, D.A., Robinson, E.S., and Johnston, P.G. Single nucleotide primer extension (SnuPE) analysis of the G6PD gene in somatic cells and oocytes of a kangaroo (Macropus robustus). Genetical Research 75:269-274, 2000. [Article Abstract] [Full Text Article in PDF]

Wilcken, D.E.L., Wang, X.L., Adachi, T., Hara, H., Duarte, N., Green, K., and Wilcken, B. The relationship between homocysteine and superoxide dismutase in homocystinuria and its relevance to cardiovascular risk. Arterioscler. Thromb. Vasc. Biol. 20:1199-1202, 2000. [Article Abstract] [Full Text Article in PDF] [Full Text Article in HTML]